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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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[Pharmacotherapy in nursing homes].

Hege Kersten1, Sabine Ruths, Torgeir Bruun Wyller

  • 1Undervisningssykehjemmet i Oslo, Abildsø bo- og rehabiliteringssenter, Løvsetdalen 2, 1188 Oslo, og Geriatrisk avdeling, Oslo universitetssykehus, Ullevål, Norway. hege.kersten@farmasi.uio.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 17, 2009
PubMed
Summary

Nursing home residents face high drug risks. Better physician staffing in one home correlated with fewer medications, lower anticholinergic burden, and fewer drug-related problems, improving resident safety.

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Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Healthcare Management

Background:

  • Nursing home residents are at high risk for drug-related problems due to polypharmacy and multi-morbidity.
  • Age-related physiological changes can exacerbate medication risks in this population.

Purpose of the Study:

  • To compare drug use and pharmacotherapy quality in two nursing homes with differing physician staffing levels.
  • To identify factors influencing drug-related problems in long-term care settings.

Main Methods:

  • A comparative study involving 48 long-term patients from two nursing homes in Oslo.
  • Pharmacists recorded drug use and identified drug-related problems, classifying drugs by anticholinergic burden.
  • Physicians assessed the clinical significance of identified drug-related problems.

Main Results:

  • Nursing home A, with better physician staffing, had significantly lower median drug use (7.0 vs 9.5 drugs) and anticholinergic burden scores (1.0 vs 2.0).
  • Patients in nursing home A experienced fewer drug-related problems (median 3.0 vs 5.5).
  • No significant differences were observed in patient age, co-morbidity, kidney function, or dementia status between the homes.

Conclusions:

  • Significant variations in medication use and quality indicators exist between nursing homes.
  • Enhanced physician staffing may contribute to improved medication management and reduced drug-related problems.
  • Systematic, multidisciplinary medication reviews are crucial for enhancing quality of care in nursing homes.