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Updated: Jun 20, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Sleep-related breathing disorders]
Harriet Akre1, Britt Øverland, Olav Skatvedt
1Øre-nese-hals-avdelingen, Lovisenberg Diakonale Sykehus, 0440 Oslo, Norway. harriet.akre@lds.no
Insights
Sleep-related breathing disorders (SRBD), including Obstructive Sleep Apnoea Syndrome (OSAS), affect 10-15% of children and adults. Early diagnosis and treatment are crucial to prevent reduced cognitive function and improve quality of life.
Area of Science:
- Sleep Medicine
- Respiratory Medicine
Context:
- Sleep-related breathing disorders (SRBD) encompass various conditions affecting sleep quality and respiratory function.
- Prevalence rates for SRBD are significant, impacting approximately 10-15% of both pediatric and adult populations.
Purpose:
- To provide a comprehensive overview of SRBD, detailing their etiology, diagnostic methods, available treatments, and the consequences of untreated disease.
- To highlight the specific characteristics and management of Obstructive Sleep Apnoea Syndrome (OSAS), the most severe form of SRBD.
Summary:
- SRBD symptoms include snoring, observed apneas, and daytime sleepiness in adults, while children may exhibit hyperactivity and learning difficulties.
- Diagnosis requires a sleep study, with continuous positive-pressure ventilation as a primary treatment for moderate to severe cases. Surgery is the preferred option for children.
- Untreated SRBD leads to increased mortality and morbidity, including reduced cognitive function and diminished quality of life in affected individuals.
Impact:
- Effective management of SRBD can mitigate serious health consequences, improving patient outcomes and overall well-being.
- Understanding the diverse manifestations and treatment options for SRBD is essential for healthcare providers to offer optimal patient care.
Background:
Sleep-related breathing disorders (SRBD) is a term that includes several different diagnoses. This paper describes aetiology, diagnostics, treatment options and consequences of untreated disease, in children and adults.
Material And Method:
The paper is based on own clinical experience and literature identified through a non-systematic search of PubMed and various books.
Results:
The prevalence of SRDB in children and adults is about 10-15% and that for the most serious type, OSAS (Obstructive Sleep Apnoea Syndrome), is about 2-4%. A sleep study is required to confirm the diagnosis. The clinical symptoms of SRBD in adults are heavy snoring, observed apnoeas, gasping for air leading to frequent arousals, disturbed sleep and daytime sleepiness. Children are often hyperactive and have learning and behaviour difficulties. Untreated patients have increased mortality and morbidity. The primary treatment option for patients with medium to serious breathing disorders is continuous positive-pressure ventilation. Other treatment options are oral devices and surgery. In children, surgery (adenotonsilectomy) is the treatment of choice.
Interpretation:
OSAS is the most severe diagnosis among SRBD. Both adults and children show reduced cognitive function and quality of life. Various treatment options are available.
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