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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow
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Human Mesenchymal Stem Cell Processing for Clinical Applications Using a Closed Semi-Automated Workflow

Published on: March 17, 2023

"Opening" the mesenchymal stem cell tool box.

Fares Zeidán-Chuliá1, Mami Noda

  • 1Medical Biochemistry and Developmental Biology, Institute of Biomedicine, University of Helsinki, Finland.

European Journal of Dentistry
|September 17, 2009
PubMed
Summary

Mesenchymal stem cells (MSCs) show promise for tissue engineering and cell therapy due to their self-renewal and differentiation capabilities. Challenges remain in their long-term integration and differentiation at injury sites, requiring further research into underlying signaling pathways.

Keywords:
Adult mesenchymal stem cellCell-based therapyDental pulpDifferentiationTissue engineeringTooth replacement

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Area of Science:

  • Regenerative Medicine
  • Cell Biology
  • Biotechnology

Background:

  • Adult mesenchymal stem cells (MSCs) are multipotent stromal cells with self-renewal and differentiation potential.
  • MSCs exhibit low tumorigenicity and immunogenicity, making them suitable for therapeutic applications.
  • Current research focuses on overcoming challenges in MSC integration and differentiation for clinical use.

Purpose of the Study:

  • To review the current status and potential of MSCs in tissue engineering and cell-based therapies.
  • To discuss the broad applications of MSCs, including neuronal and dental tissue regeneration.
  • To highlight key challenges and future directions for clinical applications of MSCs.

Main Methods:

  • This review summarizes existing literature on mesenchymal stem cells.
  • It analyzes the properties and applications of MSCs in various tissue engineering contexts.
  • The review discusses current limitations and future prospects for clinical translation.

Main Results:

  • MSCs possess significant potential for regenerating diverse tissues, from neural to dental.
  • Their inherent properties, such as low immunogenicity, enhance their therapeutic value.
  • Efficient long-term integration and differentiation at lesion sites remain key challenges.

Conclusions:

  • MSCs represent a promising tool for bioengineering and cell-based therapies.
  • Further research is needed to elucidate signaling pathways governing MSC integration and differentiation.
  • Addressing current challenges will pave the way for broader clinical applications of MSCs.