Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Autografts with peripheral blood stem cells].

Y Takaue1, T Ninomiya

  • 1Department of Pediatrics, University of Tokushima.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|May 1, 1990
PubMed
Summary

Peripheral blood stem cell (PBSC) autografts can lead to faster hematopoietic recovery, especially with adequate progenitor cell doses. This approach shows promise for prolonged remission and cure in pediatric cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lenvatinib for patients with previously treated advanced thymic carcinoma in real-world settings.

ESMO open·2025
Same author

High-Resolution Detection of Translocation of Oral Bacteria to the Gut.

Journal of dental research·2023
Same author

Corrigendum to 'Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study': [ESMO Open Volume 6, Issue 4, August 2021, 100191].

ESMO open·2022
Same author

Gefitinib induction followed by chemoradiotherapy in EGFR-mutant, locally advanced non-small-cell lung cancer: LOGIK0902/OLCSG0905 phase II study.

ESMO open·2021
Same author

Periodontitis Is Associated with Chronic Obstructive Pulmonary Disease.

Journal of dental research·2019
Same author

Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats.

The British journal of oral & maxillofacial surgery·2018

Area of Science:

  • Hematology
  • Pediatric Oncology
  • Stem Cell Transplantation

Context:

  • Reports clinical and laboratory experience of peripheral blood stem cell (PBSC) autografts.
  • Focuses on pediatric patients with various cancers.
  • Details leukapheresis procedures and autograft administration.

Purpose:

  • To evaluate the efficacy of PBSC autografts in pediatric cancer patients.
  • To determine factors influencing hematopoietic recovery post-transplantation.
  • To assess outcomes of chemotherapy-conditioning without total body irradiation.

Summary:

  • Twenty-eight children underwent 90 leukaphereses for PBSC collection, with 17 receiving autografts.
  • Frozen-thawed progenitor cell dose significantly impacts hematopoietic recovery rate.
  • Patients receiving >1 x 10(5) CFU-GM/kg showed faster granulocyte recovery.
  • Disease-free survival was observed in 6/14 high-risk acute leukemia/non-Hodgkin's lymphoma patients post-chemotherapy.

Impact:

  • Highlights the importance of progenitor cell dose for successful engraftment.
  • Suggests that PBSC autografting with chemotherapy conditioning can induce prolonged remission.
  • Offers a potential curative approach for pediatric cancers, improving long-term outcomes.

Related Experiment Videos