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Related Experiment Videos

D-2 dopamine autoreceptor selective drugs: do they really exist?

B Drukarch1, J C Stoof

  • 1Department of Neurology, Medical Faculty, Free University, Amsterdam, The Netherlands.

Life Sciences
|January 1, 1990
PubMed
Summary

Dopamine D-2 autoreceptors and postsynaptic D-2 receptors are pharmacologically similar, despite in vivo studies suggesting differences. In vitro and in vivo findings indicate these dopamine receptors are likely identical entities.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Dopamine, a key neurotransmitter, acts via D-1 and D-2 receptors.
  • D-2 receptors modulate dopamine neuron activity (autoreceptors) and target cells (postsynaptic).

Purpose of the Study:

  • To reconcile conflicting in vivo and in vitro findings on dopamine D-2 receptor pharmacology.
  • To determine if dopamine autoreceptors and postsynaptic D-2 receptors are distinct entities.

Main Methods:

  • Review and discussion of in vivo (electrophysiological, behavioral) studies.
  • Review and discussion of in vitro (biochemical) studies on brain and pituitary tissue.

Main Results:

  • In vivo studies suggested D-2 agonists are more potent at autoreceptors than postsynaptic receptors.

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  • In vitro studies found no significant pharmacological differences between autoreceptors and postsynaptic D-2 receptors.

    • Conclusions:

    • Both dopamine autoreceptors and postsynaptic D-2 receptors are concluded to be similar, if not identical.
    • The pharmacological distinctions observed in vivo may not reflect true receptor differences.