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Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
Published on: May 10, 2019
Behaviorally measured audiograms and gap detection thresholds in CBA/CaJ mice
Kelly E Radziwon1, Kristie M June, Daniel J Stolzberg
1Department of Psychology, University at BuValo, The State University of New York, BuValo, NY 14260, USA.
Summary
CBA/CaJ mice show peak auditory sensitivity between 8-24 kHz and excellent temporal gap detection abilities, with thresholds around 1-2 ms in broadband noise. These findings establish crucial baseline data for auditory research in mice.
Area of Science:
- Auditory Neuroscience
- Animal Behavior
- Psychoacoustics
Background:
- Establishing baseline auditory thresholds in mouse models is crucial for auditory research.
- CBA/CaJ mice are a common strain used in auditory studies.
- Understanding auditory perception in mice aids in the study of genetically modified models.
Purpose of the Study:
- To determine tone detection and temporal gap detection thresholds in CBA/CaJ mice.
- To revise and establish absolute auditory thresholds for the CBA/CaJ mouse strain.
- To provide essential behavioral data for auditory research.
Main Methods:
- Utilized a Go/No-go procedure and the method of constant stimuli.
- Constructed audiograms for five CBA/CaJ mice across an 8-frequency range (1-42 kHz).
- Measured gap detection thresholds in broadband and narrowband noise bursts at various sensation levels.
Main Results:
- Audiograms revealed peak sensitivity in CBA/CaJ mice between 8 kHz and 24 kHz.
- Gap detection thresholds in broadband noise were 1-2 ms, increasing at low sensation levels.
- Low-pass filtered noise (cutoff < 18 kHz) significantly increased gap detection thresholds.
Conclusions:
- Revised absolute auditory thresholds for CBA/CaJ mice were established.
- CBA/CaJ mice exhibit excellent temporal gap detection capabilities.
- This study provides vital baseline auditory data for normal-hearing mice, supporting research on genetically altered models.
