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Updated: Jun 20, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
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Published on: September 15, 2017

[Recommendations on therapy using interleukin-1beta-blocking agents].

B Manger1, M Gaubitz, H Michels

  • 1Medizinische Klinik III mit Poliklinik, FA Universität Erlangen-Nürnberg, 91054 Erlangen. bernhard.manger@uk-erlangen.de

Zeitschrift Fur Rheumatologie
|September 17, 2009
PubMed
Summary
This summary is machine-generated.

Anakinra is recommended for rheumatoid arthritis and Still's disease in Germany when other treatments fail. Interleukin-1 blocking therapies are also options for cryopyrin-associated periodic syndromes.

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Area of Science:

  • Rheumatology
  • Immunology

Context:

  • Anakinra (ANR) is the sole interleukin-1beta (IL-1beta) inhibitor available in Germany as of August 2009.
  • Recommendations for ANR use are based on published data and clinical experience by the German Society of Rheumatology.

Purpose:

  • To outline the recommended indications for anakinra (ANR) in Germany.
  • To discuss alternative IL-1 blocking therapies for specific conditions.

Summary:

  • Anakinra is indicated for rheumatoid arthritis and adult/juvenile-onset Still's disease unresponsive to conventional treatments.
  • Cryopyrin-associated periodic syndromes (CAPS) can be treated with IL-1 blocking agents like rilonacept and canakinumab.

Impact:

  • Provides guidance for rheumatologists and pediatric rheumatologists on anakinra usage.
  • Highlights the availability and efficacy of IL-1 blocking therapies for specific autoimmune and autoinflammatory conditions.