Related Experiment Video

Updated: Jun 20, 2026

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy
07:20

Repeated Transcranial Magnetic Stimulation Combined with Action Observation Training in Children with Spastic Cerebral Palsy

Published on: August 9, 2024

[Neuromodulation of spasticity in children by intrathecal baclofen]

R Cumlivski1, G Redl, W Strobl

  • 1Abteilung für Anästhesie und Intensivmedizin, Orthopädisches Spital Speising GmbH, Speisinger Str. 109, 1130, Wien, Osterreich.

Schmerz (Berlin, Germany)
|September 17, 2009
PubMed

Insights

Intrathecal baclofen (ITB) therapy effectively reduces spasticity and pain in children with cerebral spasticity. This treatment also improves motor function, daily activities, and overall quality of life.

Area of Science:

  • Neurology
  • Pediatric Orthopedics

Context:

  • Cerebral spasticity significantly impacts motor function and quality of life in pediatric patients.
  • Intrathecal baclofen (ITB) is a therapeutic option for managing complex spasticity.

Purpose:

  • To evaluate the efficacy of ITB in pediatric patients with complex neuromotoric spasticity.
  • To assess the impact of ITB on spasticity, pain, motor function, and daily living activities.

Summary:

  • A study involving 15 pediatric patients (ages 3-16) treated with ITB showed significant reductions in spasticity (Ashworth scale) and pain intensity (VAS).
  • Patients experienced improved sitting time, decreased need for nursing care, and enhanced emotional state, swallowing, head posture, and concentration.
  • The average spasticity score decreased from 4.38 to 3.0, pain intensity from 4.2 to 0.6, and nursing time from 7.5 to 3.4 on the VAS scale.

Impact:

  • ITB therapy demonstrates significant benefits for children with complex cerebral spasticity.
  • The findings suggest ITB is a valuable neuromodulation technique for improving functional outcomes and well-being in pediatric populations.
  • This study highlights the potential of ITB to enhance daily living and reduce care burden in children with severe spasticity.
Abstract

More Related Videos

Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery07:27

Targeting the Corticospinal Tract in Neonatal Rats with a Double-Viral Vector using Combined Brain and Spine Surgery

Published on: June 30, 2021

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice04:41

Lumbar Intrathecal Injection of SOD1-ASOs for Precise CNS Targeting and Predictive Efficacy in Human SOD1-G93A ALS Mice

Published on: February 24, 2026

Related Concept Videos

Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
Spasmolytic Agents: Chemical Classification01:29

Spasmolytic Agents: Chemical Classification

Spasmolytic agents are drugs used to alleviate muscle spasms and spasticity. They can be categorized into different chemical groups based on their mechanisms of action. Centrally acting spasmolytics primarily affect the spinal cord, while others directly target skeletal muscle cells.
A major class of centrally acting spasmolytics is the α2-agonist, such as tizanidine. These drugs bind to α2-adrenoceptors, inhibiting the release of the excitatory neurotransmitter glutamate. They also promote...
Centrally Acting Muscle Relaxants: Therapeutic Uses01:24

Centrally Acting Muscle Relaxants: Therapeutic Uses

Centrally acting muscle relaxants reduce muscle tone and tension by interfering with the postsynaptic reflexes in the central nervous system.
Centrally acting drugs are classified into spasmolytic and antispasmodic drugs. Spasmolytic drugs such as baclofen, diazepam, and tizanidine inhibit spinal motor neurons and decrease muscle tone. Spasmolytic drugs are administered for severe and chronic spasms due to multiple sclerosis, cerebral palsy, stroke, and spinal cord and muscle injuries. However,...