Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
Transgenic Plants02:50

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...
Transgenic Organisms00:53

Transgenic Organisms

Overview
Transgenic Organisms00:53

Transgenic Organisms

Overview
Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deriving toxicological reference values for dietary inorganic arsenic exposure from epidemiological evidence of cardiovascular disease risk.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
Same author

AI and Biotechnology to Combat Aflatoxins: Future Directions for Modern Technologies in Reducing Aflatoxin Risk.

Toxins·2025
Same author

A computational approach to understanding effort-based decision-making in depression.

Psychological medicine·2025
Same author

Assessing causal relationships between lead exposure and non-cancerous health effects through the Bradford Hill Criteria.

Critical reviews in food science and nutrition·2025
Same author

Can AI help authors prepare better risk science manuscripts?

Risk analysis : an official publication of the Society for Risk Analysis·2025
Same author

Opinion: Advancing science in support of sustainable bio-innovation: 16th ISBR Symposium - in memory of Professor Alan Raybould.

Frontiers in bioengineering and biotechnology·2025

Related Experiment Video

Updated: Jun 20, 2026

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes
07:42

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes

Published on: January 10, 2022

Problem formulation in the environmental risk assessment for genetically modified plants.

Jeffrey D Wolt1, Paul Keese, Alan Raybould

  • 1Biosafety Institute for Genetically Modified Agricultural Products, Iowa State University, Ames, IA, USA. jdwolt@iastate.edu

Transgenic Research
|September 17, 2009
PubMed
Summary

Rigorous problem formulation (PF) enhances environmental risk assessments (ERAs) for genetically modified (GM) plants. Harmonizing PF globally improves ERA consistency and decision-making relevance for GM plant regulation.

More Related Videos

Assessing Cytotoxicity of Metabolites of Typical Triazole Pesticides in Plants
08:22

Assessing Cytotoxicity of Metabolites of Typical Triazole Pesticides in Plants

Published on: December 22, 2023

Elucidating the Metabolism of 2,4-Dibromophenol in Plants
06:54

Elucidating the Metabolism of 2,4-Dibromophenol in Plants

Published on: February 10, 2023

Related Experiment Videos

Last Updated: Jun 20, 2026

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes
07:42

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes

Published on: January 10, 2022

Assessing Cytotoxicity of Metabolites of Typical Triazole Pesticides in Plants
08:22

Assessing Cytotoxicity of Metabolites of Typical Triazole Pesticides in Plants

Published on: December 22, 2023

Elucidating the Metabolism of 2,4-Dibromophenol in Plants
06:54

Elucidating the Metabolism of 2,4-Dibromophenol in Plants

Published on: February 10, 2023

Area of Science:

  • Environmental Science
  • Biotechnology
  • Risk Assessment

Background:

  • Environmental Risk Assessment (ERA) is crucial for evaluating genetically modified (GM) plants.
  • The initial step, problem formulation (PF), defines the scope, goals, and methods for analysis.
  • Current ERAs for GM plants can lack consistency and utility.

Purpose of the Study:

  • To improve the consistency and utility of ERAs for GM plants through rigorous problem formulation.
  • To develop a harmonized approach to PF for global regulatory regimes.
  • To ensure ERA outcomes are relevant for decision-making.

Main Methods:

  • Convening an international expert group under the International Life Sciences Institute (ILSI) Research Foundation.
  • Analyzing the components of problem formulation in ERA.
  • Developing recommendations for a harmonized PF approach.

Main Results:

  • Rigorous problem formulation leads to a clear analysis plan, including exposure scenarios and potential consequences.
  • A well-executed PF ensures the relevance of ERA findings for regulatory decisions.
  • A harmonized PF approach can promote global uniformity in GM plant ERA.

Conclusions:

  • Enhanced problem formulation is essential for robust and consistent environmental risk assessments of GM plants.
  • A globally harmonized approach to problem formulation will improve regulatory efficiency and decision-making.
  • This work provides a framework for improving GM plant risk assessment practices worldwide.