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Remote Neuronal Activation Coupled with Automated Blood Sampling to Induce and Measure Circulating Luteinizing Hormone in Mice
Published on: August 25, 2023
Effects of adding luteinizing hormone activity to gonadotropin releasing hormone antagonist protocols may differ
Yong Jin Kim1, Seung-Yup Ku, Byung Chul Jee
1Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, South Korea.
Objective:
In spite of previous reports on the beneficial effects of adding exogenous luteinizing hormone (LH) activity to gonadotropin releasing hormone (GnRH) antagonist protocols for conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), these effects in various age groups are still controversial. This study was performed to evaluate the clinical efficacy of adding LH activity to GnRH antagonist protocols according to patient's age.
Methods:
In this medical record review, responses to controlled ovarian hyperstimulation (COH) and IVF/ICSI outcomes were compared between follicle stimulating hormone (FSH) alone and FSH supplemented with LH activity groups in women < or =35 years (n=135) and those 435 years (n=97), respectively.
Results:
Estradiol level on hCG day in LH-added group was higher (2.150.6+1.345.1 pg/ml vs. 1.606.2+994.6 pg/ml, P=0.011) in women < or =35 years, while it did not differ in those 435 years. Less oocytes were retrieved in LH-added group of women 435 years (8.1+6.5 vs. 5.7+3.0, P=0.013), however, this figure did not differ in those < or =35 years. Regardless of age, the clinical pregnancy rates were not different between the two groups.
Conclusions:
Supplementation of exogenous LH activity to GnRH antagonist protocols affects the COH outcomes. These LH-adding effects may vary according to patient's age.
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