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Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin
07:57

Modeling Neonatal Intraventricular Hemorrhage Through Intraventricular Injection of Hemoglobin

Published on: August 25, 2022

Coagulation abnormalities and severe intraventricular hemorrhage in extremely low birth weight infants

Andrzej Piotrowski1, Iwona Dabrowska-Wojciak, Marek Mikinka

  • 1Department of Anesthesia and Intensive Care, Pediatric University Hospital, Medical University in Lodz, ul. Sporna 36/50, Lodz, Poland. andrzej-oiom@wp.pl

The Journal of Maternal-Fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
|September 17, 2009
PubMed

Insights

Severe intraventricular hemorrhage (IVH) in extremely low birth weight (ELBW) infants is linked to significant coagulation problems. Factor VII levels were the most sensitive indicator of high-grade IVH in these vulnerable newborns.

Area of Science:

  • Neonatal Medicine
  • Pediatric Hematology
  • Developmental Biology

Background:

  • The relationship between intraventricular hemorrhage (IVH) and infant coagulation is debated.
  • Limited research exists on coagulation factors as risk factors for IVH.

Purpose of the Study:

  • To assess coagulation and fibrinolysis system levels in extremely low birth weight (ELBW) infants.
  • To determine the impact of these systems on IVH development.

Main Methods:

  • Coagulation status was evaluated in 38 ELBW infants on days 1 and 2 of life.
  • IVH severity was graded using Papile classification via cerebral ultrasonography.
  • Infants were grouped based on IVH grade: Grade III/IV (Group A) or Grade I-II/no IVH (Group B).

Main Results:

  • Infants with Grade III/IV IVH had significantly lower plasma Factor VII (FVII) on day 1.
  • FVII levels differed significantly between groups (sensitivity 100%, specificity 41% for <7% cutoff).
  • Group A showed no improvement in prothrombin and aPTT times on day 2, with a notable decline in platelet count.

Conclusions:

  • High-grade IVH in ELBW infants is associated with severe coagulation derangements.
  • Factor VII levels appear to be the most sensitive marker for high-grade IVH.
  • The cause of low FVII concentrations requires further investigation.
Abstract

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