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Updated: Jun 20, 2026
06:48
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
[Body mass index and diet affect prostate cancer development].
Constanza M López Fontana1, Gabriela M Recalde Rincón, Diego Messina Lombino
1Laboratorio de Enfermedades Metabólicas y Cáncer, Facultad de Farmacia y Bioquímica, Universidad Juan Agustín Maza, Guaymallén, Mendoza, Argentina. investigacioncap@yahoo.com.ar
Actas Urologicas Espanolas
|September 18, 2009
Summary
Maintaining a healthy weight and a diet low in unhealthy fats, while rich in omega-3 fatty acids, vitamin C, and lycopene, may reduce prostate cancer (CaP) risk. This study compared dietary factors and body mass index (BMI) in CaP patients and healthy controls.
Area of Science:
- Oncology
- Nutritional Science
- Epidemiology
Background:
- Prostate cancer (CaP) is a significant global health concern.
- Obesity and poor dietary habits are suspected contributors to CaP development.
Purpose of the Study:
- To compare body mass index (BMI) and dietary intake (fats, antioxidants) between men with CaP and a healthy control group.
- To investigate the relationship between BMI, dietary factors, and prostate cancer characteristics.
Main Methods:
- Study included 40 men (50-80 years old): 20 with CaP and 20 healthy controls.
- Methods included digital rectal exam, PSA levels, ultrasound, prostate biopsy, and nutritional interviews.
- Statistical analysis used the Student T test for independent samples.
Main Results:
- Men with CaP had a higher BMI (29.8 kg/m2) than controls (27.96 kg/m2), though not statistically significant.
- A significant positive correlation was found between BMI and tumor aggressiveness (r = 0.79, P < 0.001).
- CaP patients consumed significantly more total, saturated, monounsaturated, and polyunsaturated fats, and less omega-3 fatty acids, vitamin C, and lycopene compared to controls (p < 0.05).
Conclusions:
- A healthy BMI and a diet low in unhealthy fats are associated with reduced prostate cancer risk.
- Diets rich in omega-3 fatty acids, vitamin C, and lycopene may be protective against prostate cancer.
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