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Updated: Jun 20, 2026

Imaging Odor-Evoked Activities in the Mouse Olfactory Bulb using Optical Reflectance and Autofluorescence Signals
Published on: October 31, 2011
From the top down: flexible reading of a fragmented odor map
Diego Restrepo1, Wilder Doucette, Jennifer D Whitesell
1Department of Cell and Developmental Biology and Neuroscience Program, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 80045, USA. Diego.Restrepo@ucdenver.edu
None:
Animals that depend on smell for communication and survival extract multiple pieces of information from a single complex odor. Mice can collect information on sex, genotype, health and dietary status from urine scent marks, a stimulus made up of hundreds of molecules. This ability is all the more remarkable considering that natural odors are encountered against varying olfactory backgrounds; the olfactory system must therefore provide some mechanism for extracting the most relevant information. Here we discuss recent data indicating that the readout of olfactory input by mitral cells in the olfactory bulb can be modified by behavioral context. We speculate that the olfactory cortex plays a key role in tuning the readout of olfactory information from the olfactory bulb.
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