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HTR2A gene variation is involved in antidepressant treatment response
Susanne Lucae1, Marcus Ising, Sonja Horstmann
1Max Planck Institute of Psychiatry, Munich, Germany.
Abstract:
Two serotonin 2A receptor (HTR2A) SNPs recently reported to be associated with antidepressant treatment response in STARD (rs7997012; rs1928040) were analyzed for association with treatment response in two independent Caucasian samples of patients with a Major Depressive Episode. In the combined sample (n=637) SNP rs7997012 was significantly associated with remission after five weeks providing first replicative support for the initial finding, with, however, an inverse allelic association as compared to the STARD sample.
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