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Rapid appearance of new cerebral microbleeds after acute ischemic stroke

S-B Jeon1, S U Kwon, A-H Cho

  • 1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, Republic of Korea.

Neurology
|September 18, 2009
PubMed
Abstract

Insights

New microbleeds (MBs) can rapidly develop after acute ischemic stroke. The presence of baseline MBs and severe small vessel disease (SVD) are key predictors for new MB formation.

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Cerebral microbleeds (MBs) are small lesions on MRI, but their development speed is unknown.
  • This study investigated if MBs develop rapidly after acute ischemic stroke.

Purpose of the Study:

  • To determine the frequency, location, and predictors of new MB formation post-stroke.
  • To test the hypothesis that MBs develop rapidly after acute ischemic stroke.

Main Methods:

  • Retrospective analysis of 237 acute ischemic stroke patients with baseline and follow-up MRI within one week.
  • New MBs defined as new lesions outside the infarct area on gradient-echo (GRE) sequences.
  • Association of new MBs with demographics, risk factors, laboratory data, baseline MBs, and small vessel disease (SVD) assessed.

Main Results:

  • 31.6% of patients had baseline MBs; 12.7% developed new MBs.
  • Baseline MBs (OR 5.72) and severe SVD (OR 2.94) independently predicted new MB development.
  • New MBs occurred in lobar (51.8%), deep (30.4%), and infratentorial (17.9%) locations.

Conclusions:

  • New microbleeds can develop rapidly following acute ischemic stroke.
  • Baseline MBs and severe SVD are significant predictors for new MB development.
  • Further research is needed to understand the clinical implications and mechanisms.

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