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Dual infection with dengue virus 3 and human immunodeficiency virus 1 in Havana, Cuba

Daniel Gonzalez1, Daniel Limonta, Juan Francisco Bandera

  • 1Department of Medicine, Pedro Kouri Tropical Medicine Institute, Havana, Cuba.

Journal of Infection in Developing Countries
|September 18, 2009
PubMed

Insights

Concurrent dengue virus (DEN) and human immunodeficiency virus 1 (HIV) infections were observed in Havana during a DEN-3 epidemic. HIV-infected patients with dengue fever showed no accelerated HIV progression or decreased CD4+ cell counts.

Area of Science:

  • * Virology and Infectious Diseases
  • * Epidemiology of Viral Infections

Background:

  • * Dengue virus (DEN) and human immunodeficiency virus 1 (HIV) are prevalent in overlapping geographical regions.
  • * Limited data exists on the clinical outcomes of co-infection with DEN and HIV.

Observation:

  • * Two cases of concurrent DEN and HIV infection were identified during the 2001-2002 DEN-3 epidemic in Havana.
  • * Both patients presented with symptoms of dengue fever.

Findings:

  • * Serological confirmation of DEN infection in HIV-positive individuals.
  • * Patients maintained normal CD4+ cell counts and showed no accelerated progression of HIV disease despite symptomatic dengue fever.
  • * This represents a previously unreported occurrence of DEN-3 infection in HIV-positive individuals.

Implications:

  • * Highlights the potential for underdiagnosis of DEN/HIV co-infections in endemic areas.
  • * Suggests that symptomatic dengue may not significantly impact HIV disease progression in co-infected individuals.
  • * Underscores the need for further research into the clinical management and epidemiological surveillance of this mixed viral infection.

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