Related Experiment Video
Updated: Jun 20, 2026

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Published on: February 6, 2020
Heterocyclic amines for the construction of peptoid oligomers bearing multi-dentate ligands
Galia Maayan1, Barney Yoo, Kent Kirshenbaum
1Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003-6688, USA.
Abstract:
Peptoids are oligomers of N-substituted glycine that can be readily assembled using haloacetic acids and primary amines as synthons. Here, we report the synthesis and characterization of three new heterocyclic amines, 2-(2,2':6',2''-terpyridine-4'-yloxy) ethylamine, 2-(1,10-phenanthroline-5-yloxy) ethylamine and 8-hydroxy-2-quinolinemethylamine, and their incorporation into a series of different peptoid oligomer sequences. Since the heterocycles are all known to coordinate metal ions, the peptidomimetic products are designed to bind metal species with the potential for applications in catalysis and materials science.
More Related Videos
13:42Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets
Published on: November 2, 2011
12:02An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Related Concept Videos
EDTA: Chemistry and Properties
Complexometric Titration: Ligands
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Structure of Amines
Complexation Equilibria: The Chelate Effect
Peptide Bonds