Related Experiment Video
Updated: Jun 20, 2026

Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss
Published on: April 24, 2020
Histopathological and electrophysiological study of CO(2), Er:YAG, and CO (2) + Er:YAG laser effect on peripheral
Savaş Serel1, Burak Kaya, Yildirim Sara
1Ankara Universitesi Tip Fakültesi, Plastik ve Rekonstrüktif Cerrahi, Ad Cebeci Hastanesi, Dikimevi, Ankara, Turkey. savasserel@hotmail.com
Background:
The purpose of this study was to investigate the morphological, histopathological, and electrophysiological changes of peripheral nerve after CO(2) (carbon dioxide), Er:YAG (erbium:yttrium aluminum garnet), and CO(2) + Er:YAG laser irradiation. There have been no comparative reports on CO(2), Er:YAG, and CO(2) + Er:YAG laser effects on peripheral nerve.
Methods:
Thirty Wistar albino rats were randomly assigned to three groups. Group I received CO(2), group II Er:YAG, and group III CO(2) + Er:YAG laser irradiation. Contralateral untreated sciatic nerves from the same animals were used as controls. The effect of laser on the peripheral nerve was assessed morphologically, histopathologically, and electrophysiologically after 6 weeks of laser irradiation.
Results:
No significant difference was observed between the treated and the untreated nerves.
Conclusion:
The overall findings indicated that CO(2), Er:YAG, and CO(2) + Er:YAG lasers may be used safely in nerve tissue surgery.

