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Hemodynamic effects of different H2-receptor antagonists
H Hinrichsen1, A Halabi, W Kirch
1I. Medical Department, Christian-Albrechts-Universität, Kiel, West Germany.
Clinical Pharmacology and Therapeutics
|September 1, 1990
Summary
Famotidine, unlike cimetidine and ranitidine, negatively impacted cardiac performance in healthy volunteers. This study assessed hemodynamic effects of H2-receptor antagonists, finding famotidine altered stroke volume and cardiac output.
Area of Science:
- Pharmacology
- Cardiovascular Physiology
Background:
- H2-receptor antagonists are widely used for acid suppression.
- Potential cardiovascular effects of these drugs warrant investigation.
Purpose of the Study:
- To compare the acute hemodynamic effects of famotidine, cimetidine, and ranitidine in healthy individuals.
- To evaluate cardiac performance changes induced by these H2-receptor antagonists.
Main Methods:
- Randomized, placebo-controlled, double-blind study in 10 healthy volunteers.
- Oral administration of placebo, cimetidine (800 mg), ranitidine (300 mg), and famotidine (40 mg) daily for one week.
- Hemodynamic measurements (heart rate, blood pressure, systolic time intervals, impedance cardiography) at multiple time points post-dose.
Main Results:
- No significant alterations in heart rate or blood pressure were observed with any H2-receptor antagonist compared to placebo.
- Famotidine significantly decreased stroke volume, cardiac output, and the Heather Index, and increased the pre-ejection period/left ventricular ejection time ratio.
- Cimetidine and ranitidine did not produce significant changes in these cardiac parameters compared to placebo.
Conclusions:
- Famotidine demonstrated negative effects on cardiac performance, including reduced stroke volume and cardiac output.
- Cimetidine and ranitidine did not exhibit significant adverse effects on cardiac function in this study.
- These findings highlight differential cardiovascular safety profiles among H2-receptor antagonists.
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