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Related Experiment Video

Updated: Jun 20, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Cardiac catheterization technique in a closed-chest murine model.

Shintaro Nemoto1, Gilberto DeFreitas, Blase A Carabello

  • 1Department of Medicine, Houston Veterans Affairs Medical Center, Baylor College of Medicine, Houston, Texas 77030, USA.

Contemporary Topics in Laboratory Animal Science
|September 19, 2009
PubMed
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Researchers developed a simple, less invasive cardiac catheterization technique for mice. This method provides more physiologic left ventricular (LV) hemodynamics, aiding genetic studies of cardiac phenotype.

Area of Science:

  • Cardiovascular Research
  • Animal Models
  • Physiology

Background:

  • Murine models are crucial for studying genetic effects on cardiac phenotype.
  • Standardized, efficient cardiac catheterization methods are needed for accurate murine cardiovascular assessment.
  • Existing cardiac catheterization techniques in mice lack standardization.

Purpose of the Study:

  • To establish a simple, less invasive cardiac catheterization technique in a closed-chest mouse model.
  • To enable reliable measurement of left ventricular (LV) hemodynamic parameters.
  • To provide a standardized procedure for evaluating cardiac function in mice.

Main Methods:

  • Mice were anesthetized using ketamine and xylazine.
  • Microscopic isolation of right carotid arteries (common, internal, external).

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Last Updated: Jun 20, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
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Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion
13:42

A Murine Closed-chest Model of Myocardial Ischemia and Reperfusion

Published on: July 17, 2012

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  • Insertion of a 1.4 Fr. conductance catheter into the left ventricle (LV) via retrograde approach.

    • Main Results:

    • The developed technique allowed for the acquisition of physiologic LV hemodynamics.
    • Results demonstrated improved hemodynamic data compared to open-chest models.
    • The procedure is potentially combinable with echocardiography for comprehensive cardiac assessment.

    Conclusions:

    • This simple, less invasive cardiac catheterization technique is effective for closed-chest mice.
    • The method yields more physiologic hemodynamic data than open-chest approaches.
    • With a manageable learning curve, this technique can serve as a standard for murine cardiac catheterization.