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CD133 gene overexpression is frequently observed in early colorectal carcinoma
Kenji Hibi1, Makiko Sakata, Kazuma Sakuraba
1Department of Surgery, Showa University Fujigaoka Hospital, 1-30 Fujigaoka, Aoba-ku, Yokohama 227-8501, Japan. kenjih-ngy@umin.ac.jp
Background/Aims:
Recently, it has been proved that colorectal carcinoma is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells. The present study examined the CD133 gene expression in colorectal carcinomas we surgically removed.
Methodology:
The CD133 gene expression in primary tumors and corresponding normal tissues derived from 30 patients with colorectal carcinoma was examined using a quantitative reverse-transcription PCR (QRT-PCR) and evaluated the correlation between the CD133 gene expression levels and the clinicopathological findings.
Results:
An increase in CD133 expression scores was observed in Dukes A's colorectal carcinomas (1.70 +/- 2.28) compared to Dukes B and C's colorectal carcinomas (0.76 +/- 0.71) (p = 0.0860). An increase in CD133 expression scores was also observed in female colorectal carcinomas (1.29 +/- 1.56) compared to male colorectal carcinomas (0.61 +/- 0.57) (p = 0.125).
Conclusions:
CD133 gene overexpression in early colorectal cancer patients was more frequently observed than in advanced cases.
