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Detection of gastrointestinal and abdominal infections by 99mTc-antigranulocyte antibodies
Vera Artiko1, Milorad Petrović, Dragana Sobić-Saranović
1Institute for Nuclear Medicine, Clinical Center of Serbia, Visegradska 26, 11 000 Beograd, Serbia. veraart@beotel.yu
Background/Aims:
The aim of the study was detection of abdominal infections by 99mTc- antigranulocyte antibodies.
Methodology:
Total of 36 patients with clinical suspicion on abdominal or gastrointestinal infections was investigated.
Results:
There were 23 true positive (TP) findings (one pulmonary abscess, 2 subhepatic abscesses after surgery, 2 perianal fistula, 2 chronic and 4 acute appendicitis, 5 abdominal and 3 pelvic abscesses, 3 M. Crohn, one ulcerative colitis), 9 true negative (TN) (3 tumors of the coecum, 2 tumors of papilla Wateri, 2 gastric carcinoma, 2 colon carcinoma), and 4 false negative (FN) (2 abscesses subphrenic and 2 enterocolic fistula). False positive (FP) findings were not observed. The smallest lesion found was 19x18 mm. SPECT increased the number of TP findings from 17 to 23. Fifteen of 23 infectious of inflammatory lesions could be detected in the early scan. Sensitivity was 85%, specificity 100%, positive predictive value 100%, negative predictive value 69% and accuracy 89%.
Conclusion:
According to the present results, scintigraphy with 99mTc antigranulocyte antibodies is a useful method for detection and assessment of exact localization abdominal infections, which is very important for the prompt and appropriate therapy.
Insights
Scintigraphy using technetium-99m antigranulocyte antibodies effectively detects abdominal infections. This imaging method aids in precise localization, crucial for timely and appropriate patient therapy.
Area of Science:
- Nuclear Medicine
- Diagnostic Imaging
- Infectious Diseases
Background:
- Abdominal infections pose significant diagnostic challenges.
- Accurate localization is critical for effective treatment planning.
Purpose of the Study:
- To evaluate the utility of 99mTc-antigranulocyte antibody scintigraphy for detecting abdominal infections.
- To assess the sensitivity, specificity, and accuracy of this imaging modality.
Main Methods:
- Investigated 36 patients with suspected abdominal or gastrointestinal infections.
- Utilized SPECT imaging with 99mTc-antigranulocyte antibodies.
- Analyzed true positive, true negative, false positive, and false negative findings.
Main Results:
- Achieved 85% sensitivity and 100% specificity.
- Demonstrated 100% positive predictive value and 89% accuracy.
- SPECT imaging improved detection rates, identifying lesions as small as 19x18 mm.
Conclusions:
- 99mTc-antigranulocyte antibody scintigraphy is a valuable tool for diagnosing abdominal infections.
- The method allows for precise localization, guiding prompt and effective therapeutic interventions.
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