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Drug Dosing: Geriatric Patients

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

Ethical Issues

Ethical Issues

Nurses are essential in patient care, upholding the ethical principles of their profession and effectively navigating ethical dilemmas. Neglecting ethical issues can lead to inadequate patient care, compromised therapeutic relationships, and moral distress among healthcare workers.
Ethical Concerns in Healthcare:

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Updated: Jun 20, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Psychological issues in geriatric oncology.

Archna Sarwal¹, Andrew J Roth

¹Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.

Journal of the National Comprehensive Cancer Network : JNCCN

|September 19, 2009

Summary

Cancer diagnosis significantly impacts elderly patients, causing psychological distress. This article explores late-life depression, anxiety, and delirium, offering insights into coping strategies for older adults with cancer.

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Last Updated: Jun 20, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Therapeutic Massage for Psychological Well-being in Geriatric Oncology

Published on: May 22, 2026

Area of Science:

Gerontology
Oncology
Psychiatry

Background:

Cancer survival rates have improved, yet diagnosis remains challenging for elderly patients.
Cancer and its treatment induce psychological stress, exacerbated by stigma and age-related life changes.
Older adults face unique challenges, including retirement, widowhood, and other health issues, when diagnosed with cancer.

Purpose of the Study:

To discuss psychological challenges faced by elderly cancer patients.
To explore late-life depression, anxiety, and delirium in this population.
To review treatments for older adults coping with cancer.

Main Methods:

Literature review and discussion of existing research.
Analysis of psychological impacts of cancer on aging individuals.
Examination of treatment considerations for late-life mental health issues in cancer patients.

Main Results:

Cancer diagnosis can disrupt quality of life for older adults.
Psychological distress is common, influenced by disease symptoms, perceptions, and stigma.
Age-specific factors intensify the impact of cancer on mental well-being.

Conclusions:

Effective management requires addressing psychological distress alongside cancer treatment.
Interventions should consider the unique context of aging, including late-life depression, anxiety, and delirium.
Focusing on quality of life is crucial for elderly cancer patients during and after treatment.