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Assessment of Ovarian Cancer Spheroid Attachment and Invasion of Mesothelial Cells in Real Time
Published on: May 20, 2014
Primary ovarian leiomyosarcoma associated with Brenner tumor
1Department of Pathology, Shanghai First Maternity and Infant Health Hospital, Tongji University, Shanghai, China.
European Journal of Gynaecological Oncology
|September 19, 2009
Summary
Primary ovarian leiomyosarcoma (POL) is rare and has not been documented with a Brenner tumor. This case highlights the importance of thorough sampling and immunohistochemistry for accurate POL diagnosis.
Area of Science:
- Gynecologic Oncology
- Pathology
- Surgical Pathology
Background:
- Primary ovarian leiomyosarcoma (POL) is an exceptionally rare gynecologic malignancy.
- The co-occurrence of POL with a Brenner tumor is unprecedented in medical literature.
Observation:
- A unique case involving primary ovarian leiomyosarcoma associated with a Brenner tumor is presented.
- Histopathological examination revealed spindle cells with fascicular arrangement and SMA immunoreactivity in the differentiated component.
- The poorly differentiated component showed strong desmin and vimentin staining.
Findings:
- Immunohistochemical analysis was crucial for diagnosis, despite SMA negativity in the poorly differentiated component.
- Desmin and vimentin positivity in the poorly differentiated component supported the leiomyosarcoma diagnosis.
- The study underscores the diagnostic challenges posed by antigen marker loss in malignant tumors.
Implications:
- Thorough tissue sampling and comprehensive immunohistochemistry are essential for diagnosing rare ovarian tumors.
- Relying solely on epithelial membrane antigen (EMA) immunopositivity can be misleading and may not exclude leiomyosarcoma.
- This case expands the understanding of rare ovarian tumor presentations and diagnostic methodologies.
