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Oxidant/antioxidant status in recurrent aphthous stomatitis
S Arikan1, C Durusoy, N Akalin
1Departments of Biochemistry and Dermatology, Baskent University, Alanya Hospital, Yunus Emre Street No:1, 07400 Alanya/Antalya, Turkey. serapa@baskent-aln.edu.tr
Oral Diseases
|September 19, 2009
Summary
Recurrent aphthous stomatitis (RAS) is linked to oxidative stress. Lower antioxidant levels and higher lipid peroxidation indicate a compromised defense system in patients with RAS.
Area of Science:
- Oral Medicine
- Biochemistry
- Pathophysiology
Background:
- Recurrent aphthous stomatitis (RAS) is a prevalent oral mucosal disorder.
- Oxidative stress is hypothesized to play a role in RAS pathogenesis.
Purpose of the Study:
- To investigate the involvement of oxidant toxicity in recurrent aphthous stomatitis.
- To evaluate oxidative stress markers in patients with RAS.
Main Methods:
- Compared plasma malondialdehyde, erythrocyte glutathione peroxidase activity, plasma vitamin E, and selenium levels between 26 RAS patients and 20 healthy controls.
- Utilized Mann-Whitney U-test for statistical analysis.
Main Results:
- Patients with RAS exhibited significantly elevated plasma malondialdehyde levels, indicating increased lipid peroxidation.
- RAS patients showed significantly decreased erythrocyte glutathione peroxidase activity, plasma vitamin E, and selenium levels, suggesting an inadequate antioxidant defense system (P < 0.001).
Conclusions:
- Lipid peroxidation appears to be a significant factor in the development of recurrent aphthous stomatitis.
- An inadequate antioxidant defense system is implicated in the pathogenesis of RAS.
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