Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetics in the Ocean's Twilight Zone: Population Structure of the Silvery Lightfish Across Its Distribution Range.

Evolutionary applications·2026
Same author

No selection against domestication-admixture during the marine phase of an Atlantic salmon population.

Communications biology·2026
Same author

Genetic divergence of farmed Atlantic halibut (Hippoglossus hippoglossus) and potential for impact on wild populations.

BMC research notes·2026
Same author

Domestication-Admixed Atlantic Salmon (Salmo salar) Establish a Productive Population in the Wild.

Ecology letters·2026
Same author

Genetic Recovery of Two Wild Seatrout Populations Following Long-Term Stocking With Non-Native Conspecifics.

Molecular ecology·2025
Same author

Development of SNP for <i>Sebastes</i> Species Identification With Special Focus on the Cryptic Species Complex of <i>Sebastes norvegicus</i>.

Ecology and evolution·2025
Same journal

Geographic distribution of sex chromosome polymorphism in Anastrepha fraterculus sp. 1 from Argentina.

BMC genetics·2020
Same journal

Development and characterization of a pupal-colour based genetic sexing strain of Anastrepha fraterculus sp. 1 (Diptera: Tephritidae).

BMC genetics·2020
Same journal

Improvement on the genetic engineering of an invasive agricultural pest insect, the cherry vinegar fly, Drosophila suzukii.

BMC genetics·2020
Same journal

Precise single base substitution in the shibire gene by CRISPR/Cas9-mediated homology directed repair in Bactrocera tryoni.

BMC genetics·2020
Same journal

Climate stress resistance in male Queensland fruit fly varies among populations of diverse geographic origins and changes during domestication.

BMC genetics·2020
Same journal

Genetic structure and symbiotic profile of worldwide natural populations of the Mediterranean fruit fly, Ceratitis capitata.

BMC genetics·2020
See all related articles

Related Experiment Video

Updated: Jan 11, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.7K

A genetic algorithm based method for stringent haplotyping of family data.

Francois Besnier1, Orjan Carlborg

  • 1Linnaeus Centre for Bioinformatics, Uppsala University, SE-75124 Uppsala, Sweden. francois.besnier@lcb.uu.se

BMC Genetics
|September 19, 2009
PubMed
Summary
This summary is machine-generated.

We developed a novel genetic algorithm for haplotype estimation, improving Identity By Descent (IBD) probability accuracy. Our method offers a stringency parameter, allowing users to control error rates for reliable genetic analysis.

More Related Videos

Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.5K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K

Related Experiment Videos

Last Updated: Jan 11, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.7K
Rare Event Detection Using Error-corrected DNA and RNA Sequencing
10:36

Rare Event Detection Using Error-corrected DNA and RNA Sequencing

Published on: August 3, 2018

12.5K
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.5K

Area of Science:

  • Genetics
  • Bioinformatics
  • Computational Biology

Background:

  • Haplotype information refines genetic analyses like Identity By Descent (IBD) probability estimation.
  • Accurate haplotype estimation is crucial to prevent errors in genetic studies.
  • Existing methods lack user control over error tolerance in haplotype inference.

Purpose of the Study:

  • To introduce a flexible genetic algorithm for accurate haplotype estimation in family data.
  • To provide a stringency parameter for controlling error rates in haplotype inference.
  • To enhance the reliability of IBD probability calculations.

Main Methods:

  • Developed a genetic algorithm incorporating a user-defined stringency parameter.
  • Applied the algorithm to family genetic data for haplotype estimation.
  • Evaluated the impact of stringency levels on haplotype accuracy and completeness.

Main Results:

  • High stringency settings yield highly accurate haplotype data with minimal errors.
  • Low stringency settings maximize haplotype estimates but increase error rates.
  • The stringency parameter effectively balances data completeness and accuracy.

Conclusions:

  • The proposed method offers adjustable error tolerance for haplotype estimation.
  • Users can select stringency levels based on study-specific needs for error rates.
  • This flexibility enhances the method's utility across diverse genetic applications.