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Simultaneous alignment of short reads against multiple genomes

Korbinian Schneeberger1, Jörg Hagmann, Stephan Ossowski

  • 1Department of Molecular Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 37-39, D-72076 Tübingen, Germany. korbinian.schneeberger@tuebingen.mpg.de

Genome Biology
|September 19, 2009
PubMed
Summary

GenomeMapper maps short reads to multiple genomes simultaneously using a graph structure, enabling the discovery of genetic variations missed by single-reference mapping. This approach enhances polymorphism identification in genome resequencing.

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