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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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Myeloperoxidase, subclinical atherosclerosis, and cardiovascular disease events

Nathan D Wong1, Heidi Gransar, Jagat Narula

  • 1Division of Cardiology, University of California, Irvine, California, USA.

JACC. Cardiovascular Imaging
|September 19, 2009
PubMed
Abstract

Insights

Myeloperoxidase (MPO) and coronary artery calcium (CAC) together predict cardiovascular disease (CVD) events in asymptomatic adults. Combining these markers, especially elevated MPO with significant CAC, indicates a substantially higher CVD risk.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Preventive Cardiology

Background:

  • Myeloperoxidase (MPO) is an enzyme linked to cardiovascular disease (CVD) risk.
  • Its role in asymptomatic individuals and interaction with atherosclerosis needs further clarification.

Purpose of the Study:

  • To assess if myeloperoxidase (MPO) predicts future cardiovascular disease (CVD) events in asymptomatic adults.
  • To determine if subclinical atherosclerosis influences the MPO-CVD relationship.

Main Methods:

  • 1,302 asymptomatic adults without known CVD were followed for 3.8 years.
  • Myeloperoxidase (MPO) levels and coronary artery calcium (CAC) scores were measured.
  • Cox regression analysis examined the association of MPO and CAC with incident CVD events.

Main Results:

  • Higher MPO levels were associated with traditional CVD risk factors.
  • Incident CVD events were more frequent in individuals with MPO levels at or above the median (4.6% vs. 2.3%, p=0.02).
  • The combination of elevated MPO and high CAC scores (>=100) showed a significantly increased risk of CVD events (adjusted HR: 19.5).

Conclusions:

  • Elevated myeloperoxidase (MPO) and coronary artery calcium (CAC) are strong predictors of future cardiovascular events in asymptomatic adults.
  • Combining biomarker assessment (MPO) with imaging of subclinical atherosclerosis (CAC) can enhance CVD risk stratification.

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