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Updated: Jun 20, 2026
08:16
High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
[Limb arteritis in Horton disease: five cases]
L Benjilali1, Z Tazi Mezalek, J Raffali
1Service de médecine interne, hôpital Ibn Sina, Rabat, Maroc.
La Revue De Medecine Interne
|September 19, 2009
Summary
Giant cell arteritis can affect limbs, often presenting as the initial symptom. This condition may mimic arteriosclerosis, necessitating early diagnosis and treatment to prevent severe outcomes like amputation.
Area of Science:
- Vascular Medicine
- Rheumatology
- Arteritis
Context:
- Giant cell arteritis (GCA) is a systemic vasculitis typically affecting large and medium-sized arteries.
- Limb involvement in GCA is infrequently reported and often asymptomatic, leading to potential underdiagnosis.
Purpose:
- To describe the distinct characteristics of limb involvement in patients with giant cell arteritis.
- To highlight limb arteritis as a potential presenting feature of GCA.
Summary:
- A retrospective study identified 5 out of 50 (10%) GCA patients with symptomatic limb arteriopathy.
- Limb arteritis was the primary manifestation in 4 patients, presenting with arteriographic findings of occlusion or moniliform stenosis.
- Despite treatment, 4 patients required amputations due to ischemic complications.
Impact:
- Recognizing limb arteritis as a potential GCA manifestation is crucial for timely diagnosis.
- This can help differentiate GCA from arteriosclerosis, a common condition in the elderly.
- Early intervention may prevent severe ischemic complications and limb loss.
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