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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Related Experiment Video

Updated: Jun 20, 2026

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
09:42

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

Published on: August 26, 2014

[Chromoendoscopy in inflammatory bowel disease].

M Barthet1, A Desjeux, J-C Grimaud

  • 1Service de gastroentérologie, hôpital Nord, chemin des Bourrely, Marseille cedex 20, France. mbarthet@mail.ap-hm.fr

Gastroenterologie Clinique Et Biologique
|September 19, 2009
PubMed
Summary

Surveillance for colorectal cancer in inflammatory bowel disease (IBD) pancolitis is crucial, with risks increasing over time. Chromoendoscopy aids in detecting dysplasia, but systematic biopsies remain essential for IBD monitoring.

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Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

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Last Updated: Jun 20, 2026

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation
09:42

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Published on: August 26, 2014

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
07:05

Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation

Published on: December 15, 2017

Area of Science:

  • Gastroenterology and Oncology
  • Inflammatory Bowel Disease (IBD) Research
  • Colorectal Cancer Surveillance

Context:

  • Inflammatory bowel disease (IBD)-related pancolitis carries a significant risk of colorectal cancer (CRC) development over time.
  • Previous risk estimations for CRC in IBD pancolitis may have been overestimated.
  • Current surveillance strategies for IBD patients require ongoing evaluation and optimization.

Purpose:

  • To evaluate the efficacy of chromoendoscopy in the surveillance of IBD-related pancolitis.
  • To compare the diagnostic yield of targeted biopsies versus systematic biopsies for dysplasia detection.
  • To assess the role of chromoendoscopy in the context of emerging techniques like virtual chromoendoscopy.

Summary:

  • Colorectal cancer risk in IBD pancolitis increases progressively, reaching up to 18% at 30 years.
  • Chromoendoscopy, utilizing dyes like indigo carmine or methylene blue, is recommended for IBD surveillance.
  • Targeted biopsies guided by chromoendoscopy are more efficient for dysplasia detection than systematic biopsies, though the latter are still advised.

Impact:

  • Chromoendoscopy enhances the detection of dysplasia in IBD pancolitis, potentially improving patient outcomes.
  • Findings support the integration of chromoendoscopy into standardized IBD surveillance protocols.
  • Further randomized studies are needed to clarify the role of chromoendoscopy relative to other advanced imaging techniques.