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Related Concept Videos

Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...

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Related Experiment Video

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Transcutaneous Microcirculatory Imaging in Preterm Neonates
06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Implementing and validating transcutaneous bilirubinometry for neonates.

Lorne Holland1, Kenneth Blick

  • 1Dept of Pathology, University of Colorado, Aurora, CO 80045, USA.

American Journal of Clinical Pathology
|September 19, 2009
PubMed
Summary

Transcutaneous bilirubin (TcB) offers a noninvasive way to screen for neonatal jaundice. Sternum measurements show reliable results, but forehead readings may vary by race.

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Area of Science:

  • Neonatal Medicine
  • Medical Devices
  • Clinical Diagnostics

Background:

  • Noninvasive, transcutaneous bilirubin (TcB) measurement is a promising tool for assessing neonatal jaundice.
  • Existing studies show varied opinions on the clinical utility and reliability of TcB measurements.
  • Standardization and understanding influencing factors are crucial for widespread adoption.

Purpose of the Study:

  • To evaluate the accuracy and consistency of transcutaneous bilirubin (TcB) measurements against serum bilirubin (SB) standards.
  • To identify factors influencing TcB measurement bias, including laboratory methods, measurement sites, and patient demographics.
  • To determine the optimal conditions for using TcB as a reliable screening tool for neonatal hyperbilirubinemia.

Main Methods:

  • Paired TcB and SB measurements were collected from 343 term neonates.
  • The BiliCheck meter was used for TcB measurements.
  • Three different serum bilirubin laboratory methods were employed for comparison.

Main Results:

  • Correlations between SB and TcB were consistent across all laboratory methods and measurement sites.
  • TcB bias demonstrated variability based on the specific SB method and the chosen measurement site.
  • Racial differences in TcB bias were observed for forehead measurements but not for sternum measurements.
  • Sternum TcB measurements showed less bias compared to forehead measurements.

Conclusions:

  • TcB measurement is a potentially useful screening tool for neonatal jaundice, particularly when performed on the sternum.
  • Implementation requires careful consideration of the specific laboratory instrument, measurement site, and potential racial influences on forehead readings.
  • Standardization of TcB measurement protocols is essential to minimize bias and ensure reliable screening.