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Development of Compendium for Esophageal Squamous Cell Carcinoma

Development of Compendium for Esophageal Squamous Cell Carcinoma

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Androgen-responsive gene database: integrated knowledge on androgen-responsive genes.

Mei Jiang¹, Yunsheng Ma, Congcong Chen

¹State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, China.

Molecular Endocrinology (Baltimore, Md.)

|September 19, 2009

Summary

This summary is machine-generated.

The Androgen Responsive Gene Database (ARGDB) consolidates information on androgen-controlled genes, aiding research into hormone signaling and related diseases. This resource facilitates the study of androgen regulation across species.

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Area of Science:

Molecular Biology
Genomics
Bioinformatics

Background:

Androgen signaling is crucial for numerous biological functions.
Understanding androgen-regulated genes is vital for biological and medical research.
Existing resources lacked comprehensive, integrated data on androgen-responsive genes.

Purpose of the Study:

To establish a centralized, curated database of androgen-responsive genes.
To provide detailed experimental information on androgen regulation.
To facilitate research on the biological significance and disease associations of these genes.

Main Methods:

Manual curation of over 6000 PubMed abstracts and 950 publications.
Inclusion of genes experimentally verified for androgen regulation.
Integration with major bioinformatics resources (NCBI, GO, KEGG).

Main Results:

The Androgen Responsive Gene Database (ARGDB) includes 1785 human, 993 mouse, and 583 rat genes.
Detailed experimental data (expression changes, response elements, etc.) are available for each gene.
Enrichment analysis revealed associations with disease pathways like prostate carcinogenesis.

Conclusions:

ARGDB offers a unified platform for accessing and updating information on androgen-regulated genes.
The database supports further evaluation of androgen regulation and its role in biological processes and diseases.
ARGDB is a valuable, user-friendly resource freely available online.