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Updated: Jun 20, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Cerebral microbleeds in ischemic stroke patients on warfarin treatment

Dilek Necioglu Orken, Gulay Kenangil, Ender Uysal

    Stroke
    |September 19, 2009
    PubMed
    Abstract

    Insights

    Warfarin treatment did not significantly alter cerebral microbleed (CMB) frequency in ischemic stroke patients. Older patients with CMBs showed more leukoaraiosis, but warfarin

    Area of Science:

    • Neurology
    • Radiology
    • Vascular Medicine

    Background:

    • Cerebral microbleeds (CMBs) indicate microangiopathy.
    • Significance of CMBs in anticoagulated patients is unclear.

    Purpose of the Study:

    • Determine CMB frequency in ischemic stroke patients on warfarin.
    • Compare CMBs and leukoaraiosis between warfarin users and controls.

    Main Methods:

    • 141 ischemic stroke patients on warfarin and 105 controls studied.
    • Gradient-echo MRI (GE-MRI) used to detect CMBs.
    • Vascular risk factors and leukoaraiosis compared.

    Main Results:

    • CMBs found in 22% of warfarin patients vs. 16% of controls (P=0.25).
    • CMB patients were older (P=0.04) and had more leukoaraiosis (P=0.008).
    • Warfarin duration did not differ between CMB groups (P=0.83).

    Conclusions:

    • Warfarin's impact on CMBs remains controversial.
    • CMBs associated with older age and leukoaraiosis in stroke patients.

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