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Updated: Jun 20, 2026
07:56
Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
Malignant hyperthermia, coexisting disorders, and enzymopathies: risks and management options
1Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, B6/319 Clinical Science Center, 600 Highland Ave., Madison, WI 53792-3272, USA. jfbenca@wisc.edu
Anesthesia and Analgesia
|September 19, 2009
Summary
Malignant hyperthermia (MH) susceptibility may be linked to various disorders, but evidence for a causal relationship is often weak. This review examines associations and offers clinical management guidance for uncertain cases.
Area of Science:
- Anesthesiology
- Medical Genetics
- Pharmacology
Background:
- Malignant hyperthermia (MH) is a severe pharmacogenetic disorder of skeletal muscle.
- Clinical episodes suggest potential associations between MH susceptibility and various syndromes, enzymopathies, and coexisting disorders.
- These associations raise concerns about heightened perioperative risk in affected individuals.
Purpose of the Study:
- To review published evidence on the association between malignant hyperthermia susceptibility and other medical conditions.
- To evaluate the strength of evidence for causal relationships.
- To provide clinical management recommendations for uncertain associations.
Main Methods:
- Systematic review of published case series and reports.
- Analysis of contracture testing results in potentially predisposed patients.
- Evaluation of evidence strength for identified associations.
Main Results:
- Evidence for a causal relationship between most reviewed conditions and MH susceptibility is weak.
- Some conditions show potential associations, but require further investigation.
- Perioperative risk assessment is crucial for patients with potential MH susceptibility.
Conclusions:
- The link between many disorders and malignant hyperthermia susceptibility remains uncertain.
- Clinical management should consider the limited evidence and potential risks.
- Further research is needed to clarify these associations and guide treatment.
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