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Short communication: progression of Johne's disease curtailed by a probiotic

R E Click1, C L Van Kampen

  • 1University of Wisconsin-River Falls, River Falls 54022, USA. mbclicker@msn.com

Journal of Dairy Science
|September 19, 2009
PubMed

Insights

A novel probiotic bacterium, Dietzia ssp. C79793-74, shows promise in treating Johne's disease, a condition similar to Crohn's disease. This research offers a potential new therapeutic avenue for inflammatory bowel diseases linked to Mycobacterium avium ssp. paratuberculosis (MAP).

Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Gastroenterology

Background:

  • Johne's disease, caused by Mycobacterium avium ssp. paratuberculosis (MAP), shares clinical similarities with human Crohn's disease.
  • Both conditions currently lack effective preventive and curative treatments.
  • The potential role of food animals in transmitting MAP to humans is a growing concern.

Purpose of the Study:

  • To investigate the therapeutic potential of a novel probiotic bacterium against Johne's disease.
  • To explore alternative treatment strategies for MAP-associated inflammatory bowel diseases.

Main Methods:

  • A unique bacterium, Dietzia ssp. C79793-74, was administered as a probiotic to adult animals with paratuberculosis.
  • Treatment efficacy was assessed by cure rates in the affected animals.

Main Results:

  • The probiotic bacterium Dietzia ssp. C79793-74 demonstrated therapeutic effects in adult paratuberculosis.
  • A cure rate of 37.5% was achieved in the treated animals.

Conclusions:

  • Dietzia ssp. C79793-74 shows significant therapeutic potential as a probiotic for paratuberculosis.
  • This finding suggests a novel treatment approach for inflammatory bowel diseases, including those potentially linked to MAP.

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