FINE: fisher information nonparametric embedding
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Updated: Jun 20, 2026

Combined Immunofluorescence and DNA FISH on 3D-preserved Interphase Nuclei to Study Changes in 3D Nuclear Organization
Published on: February 3, 2013
Kevin M Carter1, Raviv Raich, William G Finn
1Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA. kmcarter@umich.edu
Abstract:
We consider the problems of clustering, classification, and visualization of high-dimensional data when no straightforward euclidean representation exists. In this paper, we propose using the properties of information geometry and statistical manifolds in order to define similarities between data sets using the Fisher information distance. We will show that this metric can be approximated using entirely nonparametric methods, as the parameterization and geometry of the manifold is generally unknown. Furthermore, by using multidimensional scaling methods, we are able to reconstruct the statistical manifold in a low-dimensional euclidean space; enabling effective learning on the data. As a whole, we refer to our framework as Fisher Information Nonparametric Embedding (FINE) and illustrate its uses on practical problems, including a biomedical application and document classification.
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