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Blood pressure control determines improvement in diastolic dysfunction in early hypertension

Ibrahim Almuntaser1, Azra Mahmud, Angie Brown

  • 1Department of Cardiology, St James's Hospital, Dublin, Ireland.

American Journal of Hypertension
|September 19, 2009
PubMed

Insights

Early hypertension treatment improves diastolic dysfunction, with blood pressure control and enhanced systolic function being key factors. This study shows early improvements in diastolic function are linked to blood pressure reduction.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Echocardiography

Background:

  • Diastolic dysfunction is prevalent in early hypertension.
  • Hypothesized that diastolic dysfunction improvement is blood pressure-dependent and occurs early in treatment.

Purpose of the Study:

  • To investigate the relationship between blood pressure control and early improvement in diastolic dysfunction in newly diagnosed hypertensive patients.
  • To assess the impact of antihypertensive treatment on left ventricular (LV) diastolic function.

Main Methods:

  • 40 untreated hypertensive patients with diastolic dysfunction received either bendroflumethiazide or candesartan.
  • Echocardiography, including tissue Doppler imaging (TDI), assessed LV structure and function (E', Sm) before and after 3 months of treatment.

Main Results:

  • Antihypertensive treatment significantly reduced blood pressure (BP) by 3 months.
  • Both drugs improved TDI E' (early diastolic velocity), significantly related to improvements in Sm (systolic myocardial velocity) and fall in systolic BP.
  • Reduction in systolic BP and TDI Sm were independent determinants of improved TDI E', independent of LVMI or RWT changes.

Conclusions:

  • Good blood pressure control and enhanced systolic function are crucial for improving diastolic function in early hypertension.
  • Early treatment of hypertension can lead to significant improvements in diastolic function.
Abstract

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