Cardiac troponin I elevation in patients with aneurysmal subarachnoid hemorrhage

Area of Science:

• Cardiology
• Neurology
• Critical Care Medicine

Background:

• Cardiac dysfunction is common after aneurysmal subarachnoid hemorrhage (SAH).
• Elevated serum cardiac troponin I (cTnI) levels are associated with SAH-related cardiac dysfunction.
• Elevated cTnI predicts adverse cardiopulmonary and neurological complications, and poor patient outcomes.

Purpose of the Study:

• To investigate the association between cardiac troponin I (cTnI) elevation and clinical factors in patients with aneurysmal subarachnoid hemorrhage (SAH).
• To determine if cTnI elevation is a predictor of complications and outcomes in SAH patients.

Main Methods:

• Retrospective review of 114 patients with aneurysmal SAH and no prior cardiac history.
• Analysis of electrocardiography and serum cTnI levels at admission.
• Statistical analysis including chi-square, t-test, and logistic regression to identify factors associated with cTnI elevation and outcomes.

Main Results:

• Higher Hunt-Hess grade, poor Glasgow Outcome Scale score, pulmonary complications, elevated heart rate, and specific aneurysm locations correlated with cTnI elevation.
• cTnI elevation and Hunt-Hess grade were significant determinants of outcome in multivariate analysis.
• Incidence and treatment duration for vasospasm did not show a significant correlation with cTnI elevation.

Conclusions:

• Serum cardiac troponin I (cTnI) is a valuable indicator of cardiopulmonary and neurological complications following subarachnoid hemorrhage (SAH).
• Monitoring cTnI levels and considering associated clinical factors can aid in managing SAH and its complications.
• Early identification of patients at risk for cardiac injury post-SAH can potentially improve treatment strategies and patient outcomes.