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Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
Published on: April 25, 2025
Fragment-based development of triazole-substituted O-galactosyl aldoximes with fragment-induced affinity and
Johan Tejler1, Bader Salameh, Hakon Leffler
1Organic Chemistry, Lund University, POB 124, SE-22100, Lund, Sweden.
Organic & Biomolecular Chemistry
|September 19, 2009
Abstract:
A fragment-based development of 3C-triazol-1-yl-O-galactopyranosyl aldoximes led to the discovery of highly selective and high affinity (K(d) down to 11 microm) small monosaccharide based inhibitors of galectin-3. Galectin-7, 8 N-terminal CRD, and 9 N-terminal CRD bound the inhibitors only weakly. The galectin-3 selectivity was hypothesized to stem from interaction of the aldoxime moiety with a site not present in the other galectins.

