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Updated: Jun 20, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
Structural interactomics: informatics approaches to aid the interpretation of genetic variation and the development
Semin Lee1, Alan Brown, William Ross Pitt
1Department of Biochemistry, University of Cambridge, Old Addenbrookes site, 80 Tennis Court Road, Cambridge, UK.
Abstract:
Here we review the use of informatics in structural interactomics, with particular emphasis on understanding interfacial contacts in the development of novel therapeutics and the interpretation of genetic variation. We describe the availability and applicability of structural databases of protein interactions which facilitate this endeavour. We demonstrate the applicability of a structural interactomics approach to the study of the fibroblast growth factor (FGF)-stimulated mitogen-activated protein kinase (MAPK) pathway.
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