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Calibrated automated thrombin generation in paediatric patients with inflammatory bowel disease

H Bernhard1, A Deutschmann, B Leschnik

  • 1Department of Paediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria.

Hamostaseologie
|September 19, 2009
PubMed

Insights

Children with inflammatory bowel disease (IBD) exhibit higher thrombin generation (TG), linked to disease activity and inflammation, not inherent disposition. This finding highlights the role of hypercoagulability in pediatric IBD.

Area of Science:

  • Pediatric Gastroenterology
  • Hematology
  • Immunology

Background:

  • Inflammatory bowel disease (IBD) in adults is linked to increased thromboembolic risk.
  • High thrombin activity may drive IBD progression.
  • The role of thrombin generation in pediatric IBD is not well understood.

Purpose of the Study:

  • To investigate thrombin generation (TG) in children diagnosed with IBD.
  • To compare TG levels in pediatric IBD patients with healthy controls.

Main Methods:

  • Calibrated automated thrombography (CAT) was used to measure TG in 20 IBD patients and 60 controls (ages 10-19).
  • Disease activity was assessed using PCDAI and PUCAI.
  • Fibrinogen, F1+F2, TAT, and TFPI levels were also analyzed.

Main Results:

  • Patients with IBD showed significantly increased endogenous thrombin potential (ETP), lag time, and time to peak compared to controls.
  • ETP and F1+F2 levels correlated significantly with disease activity indices (PCDAI/PUCAI) and fibrinogen in pediatric IBD patients.

Conclusions:

  • Pediatric IBD is associated with elevated thrombin generation.
  • The increased TG appears primarily driven by the inflammatory process rather than individual genetic predisposition.
  • These findings suggest hypercoagulability as a significant factor in pediatric IBD.
Abstract

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