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HIV infection and abnormal regional ventricular function

Hong Lai1, Alban Redheuil, Wenjing Tong

  • 1Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

The International Journal of Cardiovascular Imaging
|September 19, 2009
PubMed

Insights

HIV infection may cause subclinical heart dysfunction. This study found that HIV-positive individuals had reduced left ventricular systolic and diastolic function compared to HIV-negative individuals, indicating potential early cardiac changes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • HIV infection is a global health concern.
  • Cardiovascular disease is a leading cause of mortality in people with HIV.
  • Subclinical cardiac dysfunction may precede overt cardiovascular disease.

Purpose of the Study:

  • To investigate the impact of HIV infection on regional left ventricular function.
  • To assess systolic and diastolic strain in cardiovascularly asymptomatic individuals.

Main Methods:

  • Tagged cardiac magnetic resonance imaging (CMR) was used.
  • Harmonic phase analysis assessed regional left ventricular myocardial mid-wall peak systolic circumferential strain (Ecc) and early diastolic strain rate (SRE).
  • 19 HIV-negative and 27 HIV-positive participants were analyzed.

Main Results:

  • HIV-positive individuals exhibited lower average Ecc and SRE in 90% of left ventricular segments compared to HIV-negative individuals.
  • Statistically significant decreases in Ecc strain were observed in 3 segments.
  • Statistically significant decreases in SRE were observed in 6 segments.

Conclusions:

  • HIV infection is associated with subclinical regional left ventricular systolic dysfunction.
  • HIV infection is associated with subclinical regional left ventricular diastolic dysfunction.
  • These findings suggest early cardiac changes in individuals with HIV, even without overt cardiovascular disease.

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