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Hairy cell leukemia presenting as multiple discrete hepatic lesions
Nadav Sahar1, Ginette Schiby, Tima Davidson
1Department of Medicine E, Sheba Medical Center, Tel Hashomer 52621, Israel.
World Journal of Gastroenterology
|September 19, 2009
Summary
Hairy cell leukemia typically infiltrates the liver diffusely. This report details the first case of hairy cell leukemia presenting as distinct liver lesions, successfully treated, suggesting its consideration in unknown primary cancers.
Area of Science:
- Hematology
- Hepatology
- Oncology
Background:
- Hairy cell leukemia (HCL) commonly involves the liver through portal and sinusoidal infiltration.
- Diagnosis of hepatic HCL often relies on identifying diffuse infiltration patterns.
Observation:
- This study describes a unique presentation of hepatic HCL as multiple discrete lesions.
- This is the first reported case of HCL manifesting as distinct hepatic masses.
Findings:
- The patient with hepatic HCL presenting as discrete lesions achieved successful treatment outcomes.
- Hairy cell leukemia demonstrated an excellent response to therapy in this case.
Implications:
- Hairy cell leukemia should be considered in the differential diagnosis of discrete hepatic lesions, especially in cancer of unknown primary.
- Recognizing this alternative presentation can lead to timely and effective treatment for HCL.
