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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Formation of Dispersible Taohong Siwu Tablets
05:44

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Published on: February 3, 2023

[Study on selecting the suitable solubilizing excipients for Shengmai injection].

Shao-Feng Zhang1, Dan Yan, Hui-Ying Tang

  • 1China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing 100039, China. zhshf319@126.com

Zhong Yao Cai = Zhongyaocai = Journal of Chinese Medicinal Materials
|September 22, 2009
PubMed
Summary

Polysorbate 80 is a safe solubilizing excipient for Shengmai injection, as hemolysis tests showed it is safe at concentrations up to 0.5%. Absorption spectrometry proved more reliable for hemolysis assessment.

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Formation of Dispersible Taohong Siwu Tablets
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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

Published on: September 20, 2017

Area of Science:

  • Pharmacology
  • Drug Delivery
  • Traditional Chinese Medicine (TCM) Formulation

Background:

  • Shengmai injection, a TCM formulation, requires suitable solubilizing excipients for optimal delivery.
  • Hemolysis testing is crucial for evaluating the safety of excipients in injectable formulations.

Purpose of the Study:

  • To identify safe and effective solubilizing excipients for Shengmai injection.
  • To assess the hemolytic potential of various excipients and their combinations using absorption spectrometry.

Main Methods:

  • Hemolysis ratio determination using absorption spectrometry for Shengmai injection and potential excipients.
  • Evaluation of different concentrations and combinations of excipients, including Polysorbate 80, Polyethylene glycols, and Poloxamer 188.

Main Results:

  • Shengmai injection alone did not exhibit hemolytic effects at experimental concentrations.
  • Polysorbate 80, Polyethylene glycol 400, Polyethylene glycol 600, and Poloxamer 188 showed no hemolysis, while Polysorbate 20 induced hemolysis.
  • Combinations of Shengmai injection with high concentrations (0.75%-1%) of certain excipients resulted in hemolysis.

Conclusions:

  • Absorption spectrometry is a reliable method for hemolysis assessment, surpassing macroscopic observation in accuracy.
  • Polysorbate 80 is identified as a safe solubilizing excipient for Shengmai injection within the concentration range of 0.1% to 0.5%.