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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

Updated: Jun 20, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

[Epigenetics-related diseases and analytic methods].

Hidenobu Soejima1

  • 1Division of Molecular Genetics & Epigenetics, Department of Biomolecular Sciences, Faculty of Medicine, Saga University, Saga 849-8501, Japan. soejimah@med.saga-u.ac.jp

Rinsho Byori. the Japanese Journal of Clinical Pathology
|September 22, 2009
PubMed
Summary
This summary is machine-generated.

Epigenetics explores heritable gene function changes without altering DNA sequence. This field is vital for understanding development, diseases like cancer, and advancing life sciences.

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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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Methylated DNA Immunoprecipitation
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Methylated DNA Immunoprecipitation

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Last Updated: Jun 20, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Published on: May 6, 2022

Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain
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Optimized Analysis of DNA Methylation and Gene Expression from Small, Anatomically-defined Areas of the Brain

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Methylated DNA Immunoprecipitation

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Area of Science:

  • Molecular Biology
  • Genetics

Context:

  • Epigenetic regulation influences crucial biological processes like development, differentiation, and X inactivation.
  • Aberrant epigenetic modifications are implicated in various human diseases, notably cancer and genomic imprinting disorders.

Purpose:

  • To provide an overview of epigenetics, including key regulatory mechanisms like DNA methylation and histone modifications.
  • To outline representative analytical methods used in epigenetic research.
  • To describe epigenetic alterations and their clinical implications in diseases.

Summary:

  • Epigenetics studies heritable changes in gene expression that do not involve DNA sequence alterations.
  • Key epigenetic mechanisms include DNA methylation and histone modifications, essential for gene regulation.
  • The article details epigenetic alterations in diseases and their clinical relevance.

Impact:

  • Advances in epigenetic research offer significant benefits to human health.
  • This field holds broad implications for various life sciences, driving innovation and discovery.