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Updated: Jun 20, 2026
07:09
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
Published on: July 16, 2014
[Implication of genetic polymorphism on neuropathic pain]
Masako Iseki1, Masako Sato-Takeda
1Department of Anesthesiology and Pain Medicine, Juntendo University School of Medicine, Tokyo 113-8431.
Masui. the Japanese Journal of Anesthesiology
|September 22, 2009
Summary
Genetic polymorphism research offers insights into intractable neuropathic pain conditions like postherpetic neuralgia and CRPS. This field advances genomic personalized medicine and aids drug discovery for better clinical practice.
Area of Science:
- Pharmacogenomics
- Neurology
- Genetics
Context:
- Neuropathic pain encompasses various intractable conditions requiring diverse research approaches.
- Genetic polymorphism studies have illuminated conditions such as postherpetic neuralgia, complex regional pain syndrome (CRPS), and postoperative pain.
Purpose:
- To explore the role of genetic polymorphism in understanding and treating neuropathic pain.
- To investigate how genetic variations influence drug response and discovery for pain management.
Summary:
- Genetic polymorphism research provides critical insights into the mechanisms of neuropathic pain.
- This research facilitates the development of genomic personalized medicine, tailoring treatments to individual genetic profiles.
- Studies in genetic polymorphism contribute to drug discovery, focusing on metabolism, transporters, and receptors.
Impact:
- Accelerates the realization of genomic personalized medicine in pain management.
- Enhances clinical practice by expanding knowledge of drug interactions and patient-specific requirements.
- Improves therapeutic strategies for intractable neuropathic pain conditions through targeted drug discovery.
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