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[Cell-mediated immunity in chronic pyelonephritis].

J Zhang1

  • 1Renal Division, Ren-Ji Hospital, Shanghai Second Medical University.

Zhong Xi Yi Jie He Za Zhi = Chinese Journal of Modern Developments in Traditional Medicine
|July 1, 1990
PubMed
Summary
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Chronic pyelonephritis (CPN) patients exhibit immune cell defects. Zi-Ling capsule (ZLC) and transfer factor (TF) with antibiotics improved immune function and CPN symptoms, particularly CD4 cells.

Area of Science:

  • Immunology
  • Nephrology

Context:

  • Chronic pyelonephritis (CPN) is associated with altered immune responses.
  • Peripheral blood lymphocyte surface markers provide insights into immune status.

Purpose:

  • To investigate lymphocyte surface marker profiles in CPN patients.
  • To evaluate the immunomodulatory effects of Zi-Ling capsule (ZLC)/transfer factor (TF) and antibiotics in CPN.

Summary:

  • CPN patients showed decreased CD3, lower CD4, and higher CD8 counts, indicating cell-mediated immune defects.
  • Treatment with ZLC/TF and antibiotics increased CD3 and CD4 counts, improving CPN symptoms.
  • Immune improvements, particularly in CD4 cells, were transient after treatment cessation.

Impact:

Related Experiment Videos

  • ZLC/TF combined with antibiotics may offer a therapeutic strategy for CPN by enhancing immune function.
  • The study highlights the transient immunomodulatory effects of ZLC/TF on CD4 cells in CPN patients.