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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
[Effect of Adiponectin on endothelial dysfunction in obese rats]
Ming-Rui Li1, Gang Deng, Ye-Rong Yu
1Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China.
Summary
Adiponectin improved impaired endothelium-dependent vasodilation in rats with diet-induced obesity. This suggests Adiponectin can help reverse endothelial dysfunction in obese subjects.
Area of Science:
- Cardiovascular Physiology
- Endocrinology
- Metabolic Syndrome
Context:
- Diet-induced obesity in Sprague-Dawley rats leads to impaired endothelium-dependent vasodilation.
- Endothelial dysfunction is a key factor in cardiovascular complications associated with obesity.
Purpose:
- To investigate the effect of Adiponectin on endothelium-dependent and endothelium-independent vasodilation in a rat model of food-induced obesity.
- To determine if Adiponectin can ameliorate endothelial dysfunction in obese rats.
Summary:
- Obese rat aortic rings exhibited significantly reduced endothelium-dependent relaxation compared to control rats.
- Administration of Adiponectin restored normal endothelium-dependent vasodilation in obese rat aortic rings.
- Endothelium-independent vasodilation, measured using sodium nitroprusside, was not significantly different between obese and control rats, nor affected by Adiponectin.
Impact:
- This study demonstrates that Adiponectin can improve endothelial function in the context of diet-induced obesity.
- Findings suggest Adiponectin as a potential therapeutic target for managing vascular complications in obesity.
