Related Experiment Video
Updated: Jun 20, 2026

Site-Specific Lysine Lactylation via Genetic Code Expansion in E. coli and Mammalian Cells
Published on: February 24, 2026
Yamaguchi-type lactonization as a key step in the synthesis of marine metabolites: (+)-luffalactone
Pilar Basabe1, Olga Bodero, Isidro S Marcos
1Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caidos 1-5, 37008 Salamanca, Spain. pbb@usal.es
Abstract:
A Yamaguchi-type cyclization of 5 and subsequent photochemical oxidation of the furanic ring are the key steps in the first synthesis of the marine metabolite (+)-luffalactone 4 and its epimer at C-16, 16-epi-luffalactone, 27. With this work, we have successfully established the absolute configuration of the natural product. The key intermediate 5 was obtained from the easily accessible diacetate 6a/6b.
Related Concept Videos
Production of Organic Acids
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Loss of Carboxy Group as CO2: Decarboxylation of Malonic Acid Derivatives
Inducible Operons: lac Operon
Operons
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
