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Role of type 3 deiodinase in cancer

Monica Dentice1, Raffaele Ambrosio, Domenico Salvatore

  • 1University of Naples Federico II, Department of Molecular and Clinical Endocrinology and Oncology, Via S. Pansini 5, 80131 Naples, Italy.

Expert Opinion on Therapeutic Targets
|September 22, 2009
PubMed

Insights

Type 3 deiodinase (D3) regulates thyroid hormone (TH) levels within cells. This enzyme, highly expressed in some cancers, may serve as a novel tumor marker and therapeutic target for cancer treatment.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Thyroid hormone (TH) regulates critical cellular processes like proliferation and differentiation.
  • TH signaling involves T3 interacting with nuclear receptors, influencing gene expression.
  • Intracellular T3 levels are modulated by selenodeiodinases, including type 3 deiodinase (D3).

Purpose of the Study:

  • To review the role of type 3 deiodinase (D3) in cancer.
  • To explore D3's potential as a tumoral marker.
  • To discuss D3 as a molecular target for cancer therapy.

Main Methods:

  • Literature review focusing on D3 enzyme function in tumorigenesis.
  • Analysis of studies investigating D3 expression in various cancer types.
  • Exploration of D3's role in TH metabolism and action within tumor cells.

Main Results:

  • D3 is the primary physiological inactivator of TH.
  • D3 is highly expressed in certain developing and tumoral tissues.
  • Emerging evidence suggests D3 significantly influences TH action during cancer development.

Conclusions:

  • D3 plays a critical role in controlling TH metabolism and action in the context of cancer.
  • D3's expression in tumors presents opportunities for its use as a diagnostic marker.
  • Targeting D3 may offer a novel therapeutic strategy for cancer treatment.

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